Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Comparative Physiology

Importance of retaining sodium for land vertebrates

Peter Fuller from the Hudson Institute of Medical Research, gave an interesting talk this morning at the 9th Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference. His talk focuses on the evolution of the mineralocorticoid receptor in vertebrates. For animals living on land, the receptor responds mainly to the hormone aldosterone. The receptor can also bind the stress hormone cortisol and the sex hormone progesterone, although progesterone binding inhibits the receptor. […]

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Evolving to thrive on land

Scientists Xueping Wang, Deidra M. Balchak, Clayton Gentilcore, Nathan L. Clark, and Ossama B. Kashlan from the University of Pittsburgh are presenting their research today on how sodium channels evolved as animals moved onto land at the 9th Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Colorado. Sodium channels found in epithelial cells (ENaCs) are very important in regulating salt and water balance especially in the […]

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Researchers from around the world are discussing salt regulation and its role in hypertension and other diseases

The American Physiological Society is currently hosting the 9th Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colorado (October 2-6, 2019). The conference is geared towards researchers who are interested in epithelial sodium channels (ENaC) as well as the hormone aldosterone and their roles in kidney function and blood pressure regulation. Epithelial cells are found throughout the body (see table below) and are really important in […]

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Final 2019 Ohio Physiological Society Highlights

As you can probably tell from the prior posts, the 34th annual Ohio Physiological Society conference was a great meeting filled with exciting new developments in research. However, I would be remiss if I did not mention the outstanding students who received awards for their presentations at the conference.   Below are the 2019 Ohio Physiological Society Travel Award Winners (also pictured above). Each recipient was given $750 to attend […]

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Adapting (or not) to increasing temperatures

Birds are not the only animals experiencing massive declines in populations. Rising temperatures and heat waves, in particular, have been blamed for killing humans and animals. In fact, a new review article published in Physiology mentioned that globally, heat is “a significant natural killer of humans, with the first decade of the 21st Century seeing a 23-fold increase in human casualties from heat waves compared with the 1990s.” If current predictions hold true, […]

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New research on how treefrogs protect their cells during freezing

  Brian Stogsdill, Jim Frisbee and Dr. David Goldstein at Wright State University discussed their research at the 34th annual Ohio Physiological Society meeting on special water channels in the red blood cells of freeze-tolerant Cope’s gray treefrogs. These channels can shuttle both water and glycerol in and out of the cells to protect them from damage during freezing. Check out this video showing a treefrog waking up from a […]

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