Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

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Flexible hypoxia tolerance in frogs

In a new study published in The Journal of Neuroscience and presented at the American Physiology Summit earlier this month, graduate student Nikolaus Bueschke, postdoctoral fellow Dr. Lara Amaral-Silva and Dr. Joseph Santin (University of Missouri, Columbia) together with researchers Min Hu and Alvaro Alvarez (University of North Carolina at Greensboro), explored how bullfrogs (Lithobates catesbeianus) emerging from hibernation tolerate hypoxia while they kickstart physiological functions in ice-covered ponds. This […]

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2024 August Krogh Award Recipient: Dr. Martin Grosell

Congratulations to Dr. Martin Grosell, recipient of the 2024 August Krogh Distinguished Lectureship from the Comparative and Evolutionary Physiology section of the American Physiological Society! Dr. Grosell is professor and chair of the Department of Marine Biology and Ecology at the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science in Florida. The Krogh award is sponsored by Novo Nordisk Foundation and is awarded to a member of […]

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Guest Blog: Fasting as a strategy to build athletic diving capacity

Kaitlin Allen is a graduate student at the University of California, Berkeley where she studies the physiology of elephant seals in the laboratory of Dr. José Pablo Vázquez-Medina. She received the 2024 Dr. Dolittle Travel Award from the Comparative and Evolutionary Physiology section of the American Physiological Society to attend the 2024 American Physiology Summit in Long Beach, CA (April 4-7). Kaitlin prepared this award-winning guest blog entry to describe […]

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Nematodes exhibit signs of cancer resilience

Like the wolves of Chernobyl, small nematodes (Oscheius tipulae) in the area appear to be resistant to developing radiation-induced genetic mutations. In fact, scientists have been unable to detect any changes in their genome, in comparison to individuals living in other parts of the world, despite their highly radioactive environment. Source: SC Tintori, D Cağlar, P Ortiz, MV Rockman. Environmental radiation exposure at Chornobyl has not systematically affected the genomes […]

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Dogs and humans have a lot in common when it comes to brain tumors

The most common type of naturally occurring brain tumor in humans and their feline as well as canine companions are meningiomas. The most aggressive form in humans is Meningioma C (MenG C). Unfortunately, there is currently no treatment available for MenG C and tumors often return even after radiation and surgery. Researchers were curious whether canine meningiomas were similar to human MenG C. In a newly published study, appearing in […]

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Some organisms self-destruct after reproduction

Most mammals are iteroparous, meaning they can undergo multiple cycles of reproduction and gradually advance in age. In stark contrast, semelparous species only reproduce once before they die, as the physiological toll of mating is quite high. Examples of semelparous species include Pacific salmon, which swim upstream where they die after spawning, thus becoming nutrients for their own offspring and the environment. By only 10 months of age, male kalutas […]

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Males are not always bigger…unless they are northern elephant seals

A new study published in Nature Communications challenges the popular notion that males are usually bigger than females – at least in mammals. Their findings are consistent with Dr. Katherine Ralls who also challenged this idea in the late 1970s. In this new study, researchers looked at data collected for 429 species of animals. Rather than using averaged values from the literature, they turned to large-published datasets that included values […]

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Gray wolves living within the Chernobyl Exclusion Zone develop cancer resilience

Like humans, dogs are at risk of spontaneously developing cancer as they age. In fact, cancer is the leading cause of death for dogs (Gardner et al., 2016). Research suggests that dogs may better model cancer than rodents because the disease progression is similar to humans including involvement of the immune system, molecular pathways, variations between animals, tumor resistance to chemotherapy, and metastasis (Gardner et al., 2016). Thus, understanding and […]

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Role of sphingolipids in metabolic syndrome

Sedentary horses, like humans, have an increased risk of developing metabolic syndrome characterized by obesity and abnormal elevations in insulin concentrations (hyperinsulinemia). Insulin is a hormone released from the pancreas that is responsible for lowering blood sugar after a meal by promoting the uptake of glucose into tissues. People and animals with insulin resistance are not able to respond normally to the hormone resulting in high blood sugar.    Sphingolipids […]

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