Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Illnesses and Injuries

Resisting bird flu

I just read an interesting article from the Max Delbruck Center for Molecular Medicine in the Helmholtz Association that explained why human cells are typically quite resistant to bird flu. Bird flu (H5N1, H7N9, H5N6) does not readily spread between infected humans. In fact, most outbreaks involve only a handful to a few hundred individuals. But, on occasion, the infection can spread more easily leading to a pandemic. New research […]

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Sniffing out cancer?

I just saw an interesting review article published in Physiological Reviews that discussed the presence of olfactory (i.e. smell) receptors located outside of the nose. Say what? It turns out that these “smell” receptors are not unique to our nostrils. In fact they are found throughout our bodies. Those found in the heart may be responsible for regulating heart function, those in the immune system are thought to help destroy types […]

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Porcine heart donors

Have you heard about the research being conducted to improve the use of pig hearts for human transplants?  A recent article from Discover Magazine reported on a study in which researchers were able to keep a baboon alive for 6 months with a transplanted pig heart. While pig hearts are similar to primate hearts, a major problem with xenotransplantation is that they are not only bigger to begin with, they […]

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Could zinc be involved in forming kidney stones?

Zinc is a micronutrient that is essential for normal protein production and for various enzymes to function properly in the body. Levels are important to regulate because too much can be toxic to the kidneys whereas too little can lead to problems with immune and metabolic function as well as infertility. In a new study published in American Journal of Physiology – Renal Physiology, researchers were interested in how zinc […]

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Fish offer clues to fixing broken hearts

About a year ago we talked about how Mexican tetra (Astyanax mexicanus) may hold the clues to treating diabetes. New research shows that is not all these tiny fish can teach us. Researchers at the University College London and the University of Oxford now think these fish may hold clues to regenerating damaged heart tissue. Their findings were published in Cell Reports. Mexican tetra are freshwater fish. Over millions of years, […]

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Improving tissue integrity for transplants

Ground squirrels are known for their remarkable ability to tolerate hypothermic conditions. Humans are not. Dr. JingXing Ou (National Institutes of Health) presented an interesting talk that explored using induced pluripotent neuronal stem cells isolated from these mammalian hibernators to improve tissue integrity for organ transplants. By understanding which pathways protected ground squirrel cells from cold-damage, these pathways could be manipulated in human induced pluripotent neuronal stem cells and improve […]

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Parasite-induced metabolic disease

Dr. Rudolf Schilder (Penn State University) presented a poster yesterday reporting that male dragonflies (Libellula pulchella) are developing infection-induced metabolic disease that is similar to type 2 diabetes and obesity in vertebrates. The culprit? A protozoan parasite in the animal’s gut. It makes you wonder if parasites may be to blame for some metabolic disease cases in humans…

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Physiology in Nebraska

Continuing on our journey across the country…the University of Nebraska at Omaha hosted the Nebraska Physiological Society’s annual meeting on Saturday. This year’s keynote speaker was Dr. Timothy Musch, University Distinguished Professor in the Departments of Kinesiology & Anatomy and Physiology at Kansas State University. Dr. Musch spoke about factors that regulate blood flow to skeletal muscle and how oxygen delivery to muscle changes with chronic heart failure. Dr. Xuejun […]

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Greater Washington Area Talks Physiology

It has been a great month for physiology. This week the Washington DC, Virginia, Maryland Chapter of the American Physiological Society (dvmCAPS) held their 5th annual meeting on October 8th on The George Washington University Campus. The first Distinguished Speaker was Dr. Robert S. Balaban (above), Laboratory of Cardiac Energetics at the National Institutes of Health, who spoke about the┬áStructure and Function of Cardiac Mitochondria.┬áMitochondria are derived from bacterial ancestors […]

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Physiology in Arizona – Part 1

This past weekend the Arizona Physiological Society held their 11th annual conference on the Tempe campus of Arizona State University. There were so many oral and poster presentations on comparative physiology that I will spend this entry focusing on the oral sessions. The Keynote address was given by Dr. Michael Joyner (Mayo Clinic, Rochester) who spoke about the importance of not just focusing research efforts on reductionist approaches, including many […]

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