Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Environment

Gut-temperature axis in high altitude deer mice?

Dr. Graham Scott (McMaster University) presented intriguing research at the American Physiology Summit earlier this month in Long Beach, CA. His laboratory has been examining a potential link between the gut microbiome and the ability for deer mice to help regulate body temperature. Deer mice live in high elevations where atmospheric oxygen levels are low. This presents a physiological challenge as they have to use a lot of energy to […]

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Flexible hypoxia tolerance in frogs

In a new study published in The Journal of Neuroscience and presented at the American Physiology Summit earlier this month, graduate student Nikolaus Bueschke, postdoctoral fellow Dr. Lara Amaral-Silva and Dr. Joseph Santin (University of Missouri, Columbia) together with researchers Min Hu and Alvaro Alvarez (University of North Carolina at Greensboro), explored how bullfrogs (Lithobates catesbeianus) emerging from hibernation tolerate hypoxia while they kickstart physiological functions in ice-covered ponds. This […]

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2024 August Krogh Award Recipient: Dr. Martin Grosell

Congratulations to Dr. Martin Grosell, recipient of the 2024 August Krogh Distinguished Lectureship from the Comparative and Evolutionary Physiology section of the American Physiological Society! Dr. Grosell is professor and chair of the Department of Marine Biology and Ecology at the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science in Florida. The Krogh award is sponsored by Novo Nordisk Foundation and is awarded to a member of […]

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Nematodes exhibit signs of cancer resilience

Like the wolves of Chernobyl, small nematodes (Oscheius tipulae) in the area appear to be resistant to developing radiation-induced genetic mutations. In fact, scientists have been unable to detect any changes in their genome, in comparison to individuals living in other parts of the world, despite their highly radioactive environment. Source: SC Tintori, D Cağlar, P Ortiz, MV Rockman. Environmental radiation exposure at Chornobyl has not systematically affected the genomes […]

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Gray wolves living within the Chernobyl Exclusion Zone develop cancer resilience

Like humans, dogs are at risk of spontaneously developing cancer as they age. In fact, cancer is the leading cause of death for dogs (Gardner et al., 2016). Research suggests that dogs may better model cancer than rodents because the disease progression is similar to humans including involvement of the immune system, molecular pathways, variations between animals, tumor resistance to chemotherapy, and metastasis (Gardner et al., 2016). Thus, understanding and […]

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New research shows that muscles in hibernating animals consume energy

Hibernation allows animals to reduce their energy needs during winter, when food may be scarce and high amounts of energy would be required to maintain body temperature. These animals prepare for winter by storing body fat that can be used as fuel during hibernation. Skeletal muscles in particular have high energy needs as they make up nearly half of an animal’s body mass. They also play important roles in regulating […]

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Improving the health of fish exposed to arsenic and increasing environmental temperatures

Speaking of stress…scientists at the ICAR – National Institute of Abiotic Stress Management in India are exploring the use of dietary copper to help reduce stress and improve the health of fish exposed to environmental pollutants such as arsenic. Copper is an essential element for animals and humans. It is involved in bone formation and growth, nervous system function, metabolism, immune system function, and antioxidant production.1 Warming aquatic temperatures are […]

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Study examines how statin exposure affects cholesterol metabolism in fish

Despite its bad reputation, cholesterol serves many important functions in the body. It is necessary for normal cell structure and is a precursor for the formation of steroid hormones, vitamin D, and bile acids. Too much “bad” cholesterol (LDL), however, can promote cardiovascular diseases and nonalcoholic fatty liver disease. For this reason, many animals tightly regulate cholesterol levels in the body. Fish often have higher cholesterol levels than humans and […]

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“Gatorcicles”

Freezing temperatures are no match for alligators. Recent images emerging from Texas and North Carolina show frozen ponds and swamps dotted with alligators. Similar to animals that experience torpor, alligators are able to reduce their metabolism and heart rate to as little as three beats per minute to survive freezing temperatures. This torpor-like state is called brumation. Poking their snouts above the ice before it freezes, allows them to continue […]

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New paper explores how our complex kidneys evolved

The kidneys are remarkable organs responsible for filtering blood and creating urine. To learn more about how they do this, check out this YouTube video: The evolution of glomerular filtration is what allows animals to regulate the disposal of ions such as calcium, magnesium, sodium, potassium, and sulfate. Some solutes are reabsorbed from the urine and returned to the body with the help of sodium ions, whereas other solutes are […]

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