Life Lines by Dr. Dolittle

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Alcoholic Fish

As I prepare to leave the great city of New Orleans at the end of a fabulous conference, I can’t help but mention one final poster that I saw titled, “Depressing mitochondrial function during paradoxical anaerobism leads to an alcoholic fish.” It seemed appropriate given our conference hotel was on Bourbon Street. This poster, presented by Dr. Stanley Hillyard (University of Nevada – Las Vegas) examined desert pupfish (Cyprinodon spp). […]

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Improving tissue integrity for transplants

Ground squirrels are known for their remarkable ability to tolerate hypothermic conditions. Humans are not. Dr. JingXing Ou (National Institutes of Health) presented an interesting talk that explored using induced pluripotent neuronal stem cells isolated from these mammalian hibernators to improve tissue integrity for organ transplants. By understanding which pathways protected ground squirrel cells from cold-damage, these pathways could be manipulated in human induced pluripotent neuronal stem cells and improve […]

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Hypoxia and anoxia and reoxygenation, Oh my!

There are many examples of animals that can naturally tolerate hypoxic and anoxic conditions without exhibiting pathologies associated with reoxygenation. Here are a few examples from this year’s conference: Dr. Anthony Signore (University of Nebraska) spoke about how some hypoxia tolerant animals can use carbon monoxide, you know that gas we think of as poisonous, to improve oxygen binding to hemoglobin in hypoxic conditions. Well known for their ability to […]

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How Animals Deal with Stress

  Victor Zhang (Graduate Student working with Dr. Loren Buck at Northern Arizona University) gave an interesting talk on his research to measure stress and activity patterns in free living arctic ground squirrels. They found overall that females were less stressed than males although stress levels and activity varied during lactation. I think some human mothers can agree with those observations. Oliver Wearing (Graduate student working with Dr. Graham Scott […]

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Physiology in Arizona – Part 2

Now for highlights from the Arizona Physiological Society poster session that took place on October 5th. Alex Mohr (Graduate Student, Arizona State University – Phoenix) presented his research on dietary carotenoids, which are yellow, orange and red pigments synthesized by plants. Birds are known for using these dietary carotenoids for coloration (see the male mallard in the photo above). While some research suggests that carotenoids may also act as antioxidants in […]

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Physiology in Arizona – Part 1

This past weekend the Arizona Physiological Society held their 11th annual conference on the Tempe campus of Arizona State University. There were so many oral and poster presentations on comparative physiology that I will spend this entry focusing on the oral sessions. The Keynote address was given by Dr. Michael Joyner (Mayo Clinic, Rochester) who spoke about the importance of not just focusing research efforts on reductionist approaches, including many […]

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Ohio is talking about fixing broken hearts, the physiology of freezing, combating opioid addiction and more

The Ohio Physiological Society held their 33rd Annual Meeting at the University of Cincinnati this weekend. The keynote address was given by Dr. Mark Sussman from San Diego State University. He spoke about current research strategies that aim to improve the ability for the heart to repair itself after heart failure. Dr. Perwez Alam (University of Cincinnati) also spoke about using siRNA to try to repair heart tissue after heart attacks and […]

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