Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Illnesses and Injuries

Genetically-modified virus stops Alzheimer’s disease

Check out this video from Reuters (via YouTube). It summarizes an exciting study from researchers at Imperial College London who were able to stop the progression of Alzheimer’s disease in mice by administering a modified virus to the animals. The virus worked by preventing the formation of the characteristic amyloid plaques that are responsible for causing damage to neurons in the brain. Importantly, the virus did not result in loss […]

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Using yeast to prevent outbreaks of C. difficile infections

As the name implies, Clostrodium difficile (C. diff.) bacterial infections are difficult to treat because of antibiotic resistance. The problem with C. diff is that these bacteria release toxins that cause inflammation and diarrhea. In fact, C. diff is the number one cause of infectious diarrhea in hospitals as well as long-term care facilities. Studies have shown that probiotic yeast may help prevent C. diff infections. While these studies are exciting, much of this prior […]

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What do ‘peeps’ and ‘yo-yos’ have to do with diving?

Until now I had assumed that a “peep” was that squishy sugar-covered marshmallow treat that we enjoyed as kids and a “yo-yo” was a toy on a string. As it turns out, peep and yo-yo are also term used to described types of diving patterns. A square dive is one in which there are no excursions to the surface, known as a “peep”, except at the end of the dive, of course. This is in contrast […]

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Cancer resistance developing in Tasmanian devils

Tasmanian devils are rather large carnivorous marsupials. By large, I mean the world’s largest. In only 2 decades, the population of Tasmanian devils have declined by about 85%, landing these animals on the endangered species list. The cause: an infectious cancer called devil facial tumor disease (DFTD). As the name implies, this cancer causes facial tumors that grow so large, the victims starve to death in as little as 6 […]

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Drug increases blood flow to the brain – Implications for stroke?

Researchers from Friedrich Schiller University (Jena, Germany) and Heinrich-Heine-University (Düsseldorf, Germany) teamed up to test whether a heart failure medication that is currently being tested might also improve blood flow in the brain. Their findings were published last month in the American Journal of Physiology, Heart and Circulatory Physiology. According to the study authors, the small blood vessels in the brains of sheep closely resemble those in the human brain. Using imaging techniques, they […]

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Frigatebirds and lambs

I was checking out the award-winning American Physiological Society’s I Spy Physiology blog and came across a couple of really interesting posts about animals: “If Only Birds Could Compete in the Summer Games” This post reported a study of how frigatebirds manage to sleep during flights out at sea that can last for weeks. By measuring brain activity, the research team found that the birds were capable of actual sleep, during which time both […]

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Physiology 2016

I am very excited to report that the American Physiological Society in partnership with The Physiological Society held a joint meeting from July 29-31 in Dublin, Ireland. The keynote lectures were given by Dr. Jerry Friedman from Rockefeller University and Dr. W Jon Lederer from the University of Maryland.   Dr. Friedman spoke about his research on obesity and how genetic factors might play a role. In fact, his team was […]

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Secret to safer stem cell therapy or cure for cancer?

Researchers trying to find cures for cancer find naked mole rats rather interesting. Not only are these animals long-lived by rodent standards, they are also resistant to the development of cancer. By long-lived, we are talking up to 30 years! A team of researchers from Hokkaido University and Keio University in Japan have now isolated stem cells from the skin of naked mole rats and induced them to revert back to pluripotent stem […]

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Keeping arteries healthy, lessons from seals?

Heart rate decreases during diving in seals and other animals. Thus the ascending aorta becomes very important during diving as it helps to maintain blood pressure during prolonged dives. A new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology was designed to examine the ascending aorta of hooded seals (Cystophora cristata) and the tiny blood vessels that supply nutrients to it, called the vasa vasorum. The […]

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