Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Intelligence and Neuroscience

Extreme tolerance of dehydration stress

Talk about an extreme animal. During the rainy season annual killifish, Austrofundulus limnaeus, lay eggs that are resistant to droughts. This is an important attribute for a fish that lives in temporary pools of water. The stress-resistant embryos within the eggs literally shut down their metabolism to survive months – possibly years without water. For many fish, exposure to air (and oxygen) can cause profound oxidative stress. Remarkably, this is […]

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Anoxia tolerance in goldfish

The reason mammals are not very good at tolerating hypoxic (i.e. low oxygen) environments, is because the brain relies heavily on oxygen for metabolism. It is so stingy, it uses about 20% of the oxygen in the body to make ATP. Without oxygen, the brain has to rely on glycolysis to make ATP and this process is not good at meeting the energy requirements of the neurons, ultimately resulting in […]

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Frogs are teaching researchers about autism

Dr. Helen Willsey at the University of California San Francisco is seeking to understand how autism develops with the help of frogs. Because frogs produce thousands of embryos at the same time, she is able to quickly study the effects of many different gene alterations in the offspring. While the embryos are at the two-cell stage of development, her laboratory alters genes in just one of the cells using CRISPR-Cas9 […]

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Are humans really just upright cats?

Okay seriously, humans are not actually cats. But, humans and cats do share similar nervous system control over how we move from one place to another, i.e. locomotion as described in a recent review article published in Physiology. The ability for mammals to finely control movement depends on two main control systems located in the brain and spine as well as sensory feedback from the skin, muscles, tendons, eyes, and […]

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The evolution of sugar addiction

I have been opening Christmas cards and pondering the science of sugar addiction, admittedly while snacking on sugar cookies – ‘tis the season after all! Excess consumption of highly palatable (i.e. quite tasty) foods as well as sedentary lifestyles are thought to be at the root of the current obesity epidemic. In fact, it is thought that as many as 30% of people living in developed countries are either overweight […]

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Why being ‘bird-brained’ may actually be a compliment

It has long been suspected that birds (and reptiles) were not very smart because they lack a neocortex – the part of the brain that is responsible for working memory, perception, problem solving, and conscious thought in mammals. In stark contrast to this idea, studies have repeatedly shown that several species of birds have very good memories as well as planning and problem solving skills (see examples below), which has […]

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Your dog’s internal compass

Apparently pooping is not the only thing dogs do that align with the Earth’s magnetic field. Hunting dogs are kind of like migratory birds in their ability to roam and find their way back to the same spot, while relying on the Earth’s magnetic field. In a new study published in eLife, the same researchers that discovered how dogs prefer to poop found that hunting dogs appear to use the […]

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We all need to get some shut eye

I have to confess that I have been spending way too much time binge watching shows about sharks during this year’s Shark Week on Discovery Channel. I know I should be getting 7 hours of sleep a night…but could watching just one more show be that bad? Speaking of sleep, I am reminded of a study that I read awhile back examining whether sharks and rays need sleep. This may […]

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