Life Lines by Dr. Dolittle

Nature’s Solutions

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Can carbon monoxide be a good thing at high altitude?

Although carbon monoxide inhalation is dangerous because it can cause blood poisoning, research suggests that production of carbon monoxide in the body may actually protect cells during exposure to hypoxic environments as well as during ischemic-reperfusion injuries. Carbon monoxide is produced in the body by the enzyme heme oxygenase. This enzyme is responsible for converting heme into biliverdin and generates carbon monoxide in the process. Interestingly, carbon monoxide levels are […]

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Nature’s medicines

Although they look furry and fun to pet, larvae of asp caterpillars (like the one pictured above) would inflict pain on anyone bold enough to touch them. Underneath their “fur” lay venomous spines containing toxins that cause intense burning pain. Although other caterpillars and insects are also venomous, the particular venom produced by asp caterpillars is different. In fact, researchers at the University of Queensland in Australia think that these […]

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Wait, what? A warm-blooded, plankton-eating shark?

During this year’s Shark Week, I came across an article published in Endangered Species Research that reported on warm-blooded basking sharks (Cetorhinus maximus). While the majority of fish and sharks are cold-blooded, researchers found that the core body temperature of these endangered basking sharks is 1-1.5 degrees celsius warmer than the water in which they swim. Because not all tissues are warm, they are ‘regionally endothermic’. While it makes sense […]

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Ever wonder how a swim bladder works?

Swim bladders are special organs filled with air that help regulate the buoyancy of some bony fish, like teleosts. Check out this YouTube video which explains how the swim bladder works: Because the inner surface of this organ is lined with mucosa, researchers suspected it may contain immune cells and microbes – similar to the inner lining of mammalian lungs. In a study published in Cell Discovery, researchers confirmed the […]

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Sniffing out pathogens

Rainbow trout are able to mount an immune response after simply smelling a virus or bacteria, even before they are infected. In a new study shared at the 2023 American Physiology Summit, researchers examined whether smell-induced activation of the immune response also triggers avoidance behaviors in the fish. By creating a maze that included a pathogen at one end, they discovered that the fish do in fact avoid the smell […]

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Sodium is necessary to absorb some dietary nutrients

As frogs develop, their intestines become shorter and the cells on the inner lining of the intestine change. Researchers have suspected that these changes help the animals transition from a diet consisting of mainly algae as a tadpole to a carnivorous diet in adulthood. This was the subject of a recent study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, which examined how the intestine […]

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Physiological Desalination

Ellie Runiewicz, an undergraduate student in the laboratory of Dr. Jason Breves at Skidmore College presented research on osmoregulation in teleost fish at the American Physiology Summit last month. Ellie’s research examined how Atlantic salmon are able to remove salts from the water they drink. When these fish live in marine environments, they are constantly drinking saltwater. Processing the water to remove the salts is therefore really important to their […]

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2023 August Krogh Distinguished Lecturer – Dr. Tobias Wang, Aarhus University

Congratulations to Dr. Tobias Wang (Aarhus University), recipient of the 2023 August Krogh Distinguished Lectureship at the American Physiology Summit. Dr. Wang’s lecture, titled Digesting snakes are a feast for integrative physiology”, was fascinating! This was such a well-deserved honor. In fact, not only did he give a lecture describing his research on the digestive physiology of snakes, but he also gave an invited talk about blood pressure regulation in […]

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How snakes fight infection quickly

In honor of St. Patrick’s Day today, I thought we’d talk about snakes today. Vertebrates defend themselves from infections with the help of the adaptive and innate immune systems. The first responder to an infection is typically the innate immune system, which is not specific to a particular pathogen. This system helps to prevent the infection from spreading and uses various toxins to kill pathogens. The adaptive immune response, on […]

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Infertility is not an issue for naked mole rats

Naked mole-rats have attracted the attention of scientists once again. Not only do they live very long lives (30+ years), while typically avoiding cancer, females remain fertile their whole life. Unlocking their secrets to avoiding menopause may lead to new ways to treat infertility. New research has identified their tricks for lifelong fertility. It turns out that female naked mole-rats have 1.5 million egg cells (oocytes) when they are born, […]

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