Life Lines by Dr. Dolittle

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What dolphins can teach us about healthy aging

The risk of developing cardiovascular disease increases with aging as arteries can become increasingly stiff and the inner lining, called the endothelium, can become dysfunctional. Postdoctoral fellow Dr. Yara Bernaldo De Quiros Miranda (University of Las Palmas de Gran Canaria) is interested in understanding how bottlenose dolphins, Tursiops truncatus, protect their cardiovascular system during aging. She is currently a visiting scholar at the University of Colorado at Boulder where she […]

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Speaking of hypoxia tolerance…

Amy Klink, a graduate student working in the laboratory of Dr. Allyson Hindle at the University of Nevada, Las Vegas, has been studying hypoxia tolerance of Weddell seals. These remarkable animals can hold their breath for 90 minutes and dive as deep as 900 meters! During such long and deep dives, these seals slow down their heart rate and constrict blood vessels in visceral as well as peripheral organs. As […]

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What sea turtles can teach us about hypoxia tolerance

Imagine being able to explore the Earth’s oceans without needing special oxygen equipment. Loggerhead sea turtles have this ability and can actually hold their breath for up to 7 hours! According to the Guiness Book of World Records, Budimir Šobat from Croatia set the record in 2021 for being able to hold his breath for 24 minutes and 37.36 seconds underwater. While quite remarkable, he would need to hold his […]

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Gut-temperature axis in high altitude deer mice?

Dr. Graham Scott (McMaster University) presented intriguing research at the American Physiology Summit earlier this month in Long Beach, CA. His laboratory has been examining a potential link between the gut microbiome and the ability for deer mice to help regulate body temperature. Deer mice live in high elevations where atmospheric oxygen levels are low. This presents a physiological challenge as they have to use a lot of energy to […]

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Flexible hypoxia tolerance in frogs

In a new study published in The Journal of Neuroscience and presented at the American Physiology Summit earlier this month, graduate student Nikolaus Bueschke, postdoctoral fellow Dr. Lara Amaral-Silva and Dr. Joseph Santin (University of Missouri, Columbia) together with researchers Min Hu and Alvaro Alvarez (University of North Carolina at Greensboro), explored how bullfrogs (Lithobates catesbeianus) emerging from hibernation tolerate hypoxia while they kickstart physiological functions in ice-covered ponds. This […]

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2024 August Krogh Award Recipient: Dr. Martin Grosell

Congratulations to Dr. Martin Grosell, recipient of the 2024 August Krogh Distinguished Lectureship from the Comparative and Evolutionary Physiology section of the American Physiological Society! Dr. Grosell is professor and chair of the Department of Marine Biology and Ecology at the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science in Florida. The Krogh award is sponsored by Novo Nordisk Foundation and is awarded to a member of […]

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Guest Blog: Fasting as a strategy to build athletic diving capacity

Kaitlin Allen is a graduate student at the University of California, Berkeley where she studies the physiology of elephant seals in the laboratory of Dr. José Pablo Vázquez-Medina. She received the 2024 Dr. Dolittle Travel Award from the Comparative and Evolutionary Physiology section of the American Physiological Society to attend the 2024 American Physiology Summit in Long Beach, CA (April 4-7). Kaitlin prepared this award-winning guest blog entry to describe […]

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Nematodes exhibit signs of cancer resilience

Like the wolves of Chernobyl, small nematodes (Oscheius tipulae) in the area appear to be resistant to developing radiation-induced genetic mutations. In fact, scientists have been unable to detect any changes in their genome, in comparison to individuals living in other parts of the world, despite their highly radioactive environment. Source: SC Tintori, D Cağlar, P Ortiz, MV Rockman. Environmental radiation exposure at Chornobyl has not systematically affected the genomes […]

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Dogs and humans have a lot in common when it comes to brain tumors

The most common type of naturally occurring brain tumor in humans and their feline as well as canine companions are meningiomas. The most aggressive form in humans is Meningioma C (MenG C). Unfortunately, there is currently no treatment available for MenG C and tumors often return even after radiation and surgery. Researchers were curious whether canine meningiomas were similar to human MenG C. In a newly published study, appearing in […]

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