Life Lines by Dr. Dolittle

Tag Archive for ‘altitude’

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Thriving at high altitude

Humans have occupied high altitude environments for over 10,000 years, allowing ample time for some remarkable adaptations to hypoxia. Such adaptations we have already discussed in people living on the Tibetan Plateau (elevation: 4,500 meters on average) include higher breathing rates combined with lower levels of hemoglobin, the molecule that carries oxygen in the blood, compared to lowland populations, which helps prevent mountain sickness as well as the formation of […]

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Remarkable hypoxia and cold tolerance of rodents native to the Tibetan plateau

The plateau zokor (Eospalax baileyi) is an underground dwelling rodent species native to the Tibetan plateau (2000-4200 meters in elevation). A new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology explored how these animals were adapted to extract oxygen from an environment with very low levels (83-88% of atmospheric). Hemoglobin molecules found in red blood cells are responsible for binding oxygen and transporting it to tissues […]

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High altitude deer mice have less stress?

Animals that live at high altitude have evolved a number of physiological adaptations to deal with the low atmospheric oxygen concentrations (hypoxia). For low altitude acclimated animals, short exposures to high altitude results in activation of the sympathetic nervous system (i.e. the fight or flight response). This is a good thing because activation of this system results in more blood flow, especially to the heart and brain to help protect oxygen […]

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Experimental Biology 2017 – Day 5

Here are the highlights from the final day of the meeting: Carbon monoxide (CO) is not all that bad: Michael Tift, graduate student at Scripps Institute of Oceanography, described how the body naturally produces CO when red blood cells are broken down and CO can actually be protective against inflammation at low doses. His research was focused on measuring whether species that have more hemoglobin (from living in hypoxic environments) also have […]

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Experimental Biology 2016 – Day 4

Still going strong…here are the highlights from several sessions held on Day 4: John Eme (California State University, San Marcos) presented data testing the effects of varying temperatures mimicking overwintering conditions on embryonic development of Lake whitefish. He found that indeed exposure to variable incubation temperatures between 2-8 deg C resulted in increased mortality. Moreover, the embryos hatched earlier and were smaller than animals exposed to constant temperatures. Nariman Hossein-Javaheri et al., (University […]

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