Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Tag Archive for ‘American Journal of Physiology’

Low-calorie sweeteners – harmful or hype?

Researchers at Columbia University wanted to examine whether low-calorie sweeteners disrupt glucose tolerance as there are conflicting reports in both human and animal studies. Their results examining the link between low-calorie sweeteners and glucose regulation in mice are published in the upcoming issue of the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology. In their first experiment, the research team found no differences in glucose tolerance or body […]

Continue Reading →

Importance of feeding chicks shortly after hatching

While egg yolks are rich in lipids, chicks consume mainly carbohydrates after hatching. This ability to switch between using nutrients provided by the mother in the egg and those the chick must acquire from the environment is important for the normal growth and metabolism of the birds after hatching. Delayed access to foods after hatching can therefore have long term effects on the animals. Transport of animals from hatcheries to […]

Continue Reading →

How some fish may compensate for low environmental oxygen

     Adult fish rely on gills to extract oxygen from the surrounding water. Larval fish, on the other hand, do not have well-developed gills and instead rely primarily on gas exchange across their skin.      In a new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, researchers examined whether larval fish could use their pectoral fins to increase the flow of water […]

Continue Reading →

Researchers explore why fetuses that experienced intrauterine growth restriction have smaller muscles

We have talked several times about the long-lasting issues related to growth restriction of a fetus during pregnancy: Intrauterine growth restriction increases risk of cardiovascular disease as adults Intrauterine growth restriction increases risk of insulin resistance as adults It can also result in offspring that have smaller muscles. New research published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology suggests this may be due to adaptations to […]

Continue Reading →

Warm hypoxic waters impair heart function in some fish

Events causing bodies of water to become hypoxic (low oxygen levels) are increasing with climate change. Water can become hypoxic when it warms up or there are changes in tidal flow, density, wind patterns as well as separation from the main source, such as occurs in a tidepool. While some fish are tolerant of hypoxia and even anoxia (oxygen depleted) environments others, such as Atlantic cod and steelhead trout, rely […]

Continue Reading →

Adults are better adapted to survive without oxygen

Adult fruit flies (Drosophila melanogaster) are more tolerant of environments devoid of oxygen than their larvae. In fact, they are able to survive up to 12 hours without oxygen by becoming paralyzed, which enables them to dramatically reduce metabolism and the need for oxygen. In contrast, Drosophila larvae expend a lot of energy trying to escape and are only able to tolerate a couple of hours without oxygen. This is surprising […]

Continue Reading →

Remarkable hypoxia and cold tolerance of rodents native to the Tibetan plateau

The plateau zokor (Eospalax baileyi) is an underground dwelling rodent species native to the Tibetan plateau (2000-4200 meters in elevation). A new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology explored how these animals were adapted to extract oxygen from an environment with very low levels (83-88% of atmospheric). Hemoglobin molecules found in red blood cells are responsible for binding oxygen and transporting it to tissues […]

Continue Reading →