Life Lines by Dr. Dolittle

Tag Archive for ‘American Physiological Society’

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Primed for survival: How sea hares inspire new clues to protect the brain from low oxygen conditions such as stroke

Sea hares (Aplysia californica) live in coastal environments where oxygen levels can fluctuate unpredictably. Knowing this, researchers set out to explore how these animals tolerate regular exposure to hypoxia (low oxygen) with the hope of discovering clues that could teach us how to protect humans from hypoxia-related conditions, such as stroke. To do this, they compared offspring from two types of parents: those collected from the wild that likely experienced […]

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Brown adipose tissue: not just a heater or fat-burning machine

Once dismissed as a feature only babies possess, brown adipose tissue (BAT), is widely recognized as the body’s metabolism-boosting, heat-generating fat. This Time Machine episode takes a look back at early research and new discoveries about this metabolism-boosting fat. According to a 2007 paper published in the American Journal of Physiology – Endocrinology and Metabolism, it was the ability for BAT to take up glucose that enabled its discovery in […]

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Mosquitoes suck! (and pee, too)

As if sucking our blood wasn’t bad enough, I was horrified to learn that mosquitoes also pee on us while they’re drinking. Yuck! In this time machine, we revisit a 1987 paper published in Physiology that explains why. Female mosquitoes require blood meals to obtain the proteins necessary for egg production. During a single meal, they can consume up to twice their body mass in blood. That’s like a 150-pound […]

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Time Machine: Is lactic acid really to blame for muscle fatigue?

Have you ever experienced muscle fatigue? You know the feeling where your muscles start to burn and no matter how hard you try, you simply cannot summon any more strength? It is often assumed that the burning sensation associated with muscle fatigue is due to lactic acid building up in the muscles. But is that the full story? In this time machine post, we examine the science behind muscle fatigue […]

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Ocean oddity: how teleost fish stay hydrated in saltwater

It may sound strange to hear that saltwater fish need to stay hydrated. After all, they live in water. However, a review published in Physiology describes how nearly all saltwater fish are thought to have evolved from freshwater ancestors, and many maintain similar levels of salt in their blood as freshwater animals. Living in a saltwater environment means that these fish have to find a way to get rid of […]

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Time Machine: Keeping it hot…or not

In todays’ Time Machine, we are taking a look back at a paper written by Dr. Henry Gray Barbour during his time in the Department of Pharmacology at Yale University School of Medicine. Published in Physiological Reviews in 1921, his paper examined how body heat is regulated in various species. In this review, Dr. Barbour explains that water is the best medium for conducting heat throughout the body. This is […]

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“Hummingbirds of the Night”

A reference to nectar-feeding bats as “hummingbirds of the night” in a presentation at the 2025 American Physiology Summit in Baltimore last month caught my eye. What an appropriate nickname for bats that can have blood sugar levels exceeding 750 mg/dl after a meal! Sure, a hummingbird would think this was normal, but for a human these levels would warrant a trip to the emergency room. New research shared by […]

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The electrophysiology of sudden cardiac death in high-performance athletes

Humans and racehorses have something in common when it comes to risk of sudden cardiac death. In fact, sudden cardiac death is the 2nd most common cause of death during exercise among these athletes. Although rare, it typically affects young, seemingly healthy individuals. Research suggests that exercise itself is not to blame, but rather an underlying predisposition for irregular heart rates that exercise uncovers. The most common inherited causes of […]

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Some like it hot: Genetic twists in warm hibernation

Hibernation was also a hot…I mean warm…topic at the American Physiology Summit last month in Baltimore, MD. Thomas Crippen presented research conducted with team members Dr. Dylan Barth, Zac Carlson, Dr. Frank van Breukelen, and Dr. Allyson Hindle at the University of Nevada, Las Vegas. Their study focused on golden-mantled ground squirrels, Callospermophilus lateralis, which are remarkable even among hibernators. These squirrels can enter torpor across a range of environmental […]

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No air? No problem: Nature’s ultimate survivalists

Hypoxia and anoxia tolerance was a hot topic at the 2025 American Physiology Summit last month. Here are the highlights: Hafsa Yaseen and Natalie Anne Heath presented their research from Dr. Joseph Santin’s laboratory at the University of Missouri exploring how adult bullfrogs (Aquarana catesbeianus) protect their brain function following hibernation, a period when oxygen and glucose levels are often very low. The team discovered that bullfrogs could adjust their […]

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