Life Lines by Dr. Dolittle

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Tag Archive for ‘disease’

Dogs may facilitate spread of Rocky Mountain Spotted Fever

Alec Oliva, a graduate student at Midwestern University – Glendale campus, presented research examining the spread of Rocky Mountain Spotted Fever (RMSF) at the 2019 Arizona Physiological Society conference this past weekend. With a mortality rate as much as 80% without treatment, the spread of this disease is quite concerning. Ticks are vectors for the Rickettsia rickettsii bacteria responsible for causing RMSF. Dogs are notoriously at risk for acquiring tick infestations […]

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Researchers from around the world are discussing salt regulation and its role in hypertension and other diseases

The American Physiological Society is currently hosting the 9th Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colorado (October 2-6, 2019). The conference is geared towards researchers who are interested in epithelial sodium channels (ENaC) as well as the hormone aldosterone and their roles in kidney function and blood pressure regulation. Epithelial cells are found throughout the body (see table below) and are really important in […]

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Elasmobranchs may hold clues for treating blood disorders

As you may already know, bone marrow contains cells that specialize in both bone as well as blood maintenance. Stem cells destined to become white blood cells, red blood cells and platelets are called hematopoietic stem cells (aka: HSCs). CXCL12 is a special ligand that helps keep HSCs in the bone marrow by acting as a chemical attractant for the chemokine receptor C-X-C (CXCR4) found on HSCs. Some researchers are […]

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Zebrafish as models for human disease and drug development

  Who would have thought tiny fish could lead to big advances in medicine? Zebrafish (Danio rerio) and mammals have similar anatomy and physiology of the brain, eyes, gut, and cardiovascular systems. Some of the reasons why these fish are good models to understand cardiovascular physiology were recently explored in a new article published in Physiological Reviews. Animal models are used in research that seeks to understand both normal physiological mechanisms as […]

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