Life Lines by Dr. Dolittle

Tag Archive for ‘Drosophila’

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Physiology on the Road: Mophys 2024!

The Missouri Physiological Society (mophys) is holding their annual chapter meeting tomorrow at the University of Missouri, Kansas City (UMKC) campus! Here are just some of the highlights showcasing ways in which physiologists in Missouri are advancing science and medicine: Felix Yang (Graduate student at the University of Missouri, Kansas City; Mentor: Dr. Xiang-Ping Chu) will present research on certain ion channels in the brain that are associated with detecting […]

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It’s all about the glucose

A lack of available food resources drives many species to forego reproduction until conditions improve. In other words, there is a trade-off between reproduction and foraging. This link was the subject of a recent study of Drosophila melanogaster published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology.   To examine the link, researchers placed fed or food-deprived Drosophila into a testing arena with another animal of […]

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Physiology on the road: What’s happening in Arizona

The Arizona Physiological Society held their 16th annual meeting this past weekend at Midwestern University in Glendale, Arizona. The Arizona Established Scientist Keynote Speaker was Dr. Christopher Glembotski, Professor of Internal Medicine and Director of the Translational Cardiovascular Research Center at the University of Arizona, Phoenix campus. Ischemic diseases, such as strokes and heart attacks, disrupt the normal functioning of the endoplasmic reticulum, which alters protein production and folding. His […]

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Understanding hypoxia tolerance

Hypoxia associated with ischemic stroke, heart attacks, and solid tumors causes significant pathologies in humans. However, some populations of humans that have lived at high altitudes for generations have adaptations that provide some measures of hypoxia tolerance that may lend insight into treatments for pathological hypoxia in disease states.    Researchers seeking to understand hypoxia tolerance compared the genome of Andean and Ethiopian highlander populations with the genome of Drosophila […]

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Understanding genetic factors contributing to COPD

According to a study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, we have a lot in common with fruit flies when it comes to the layer of cells that line our airways. So much so, that researchers claim Drosophila melanogaster are important models for lung diseases such as chronic obstructive pulmonary disease (COPD). COPD is a debilitating disease that claimed the lives of over […]

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Understanding cardiomyopathy through drosophila

Courtney Petersen presented her research at the 6th annual Greater Washington DC Area Physiological Society conference today. This research was conducted with Dr. Matthew Wolf at the University of Virginia School of Medicine and Dr. Jeremy Smyth at the Uniformed Services University in Bethesda, Maryland. Courtney’s research was focused on cardiomyopathy, which is a disease of the heart’s muscle that can make it harder for the heart to pump blood […]

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Adults are better adapted to survive without oxygen

Adult fruit flies (Drosophila melanogaster) are more tolerant of environments devoid of oxygen than their larvae. In fact, they are able to survive up to 12 hours without oxygen by becoming paralyzed, which enables them to dramatically reduce metabolism and the need for oxygen. In contrast, Drosophila larvae expend a lot of energy trying to escape and are only able to tolerate a couple of hours without oxygen. This is surprising […]

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Dealing with the cold

Cold-tolerant insects have developed several strategies for dealing with cold temperatures. A new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology explored how spotted wing drosophila (Drosophila suzukii), in particular, adapted physiologically to cold exposure. They discovered that animals adapted to living in the cold had altered the structure of their cellular membranes in ways that kept the membrane fluid and prevented it from becoming rigid. Moreover, […]

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If only I were a fruit fly…

  Oh, to be a Drosophila. A new study published in Science Advances reports that male Drosophila have an amazing tolerance for sleep deprivation. I wish I could say the same about humans. Like people, sleep duration in flies varies between individuals, with some animals getting only a few minutes of sleep a day. In many other species, chronic sleep deprivation is associated with shorter lifespans. In this new study, researchers […]

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