Life Lines by Dr. Dolittle

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Tag Archive for ‘gene’

Aging and Immortality

Have you ever heard of the ‘immortal’ jellyfish, Turritopsis dohrnii? These tiny creatures (about 4.5 mm) are aptly named for their ability to essentially live forever. According to the Natural History Museum, when these jellyfish are damaged, they can actually revert to a prior life cycle as a polyp and become an adult jellyfish (aka, medusa) all over again. This process is called transdifferentiation. Check out this video from the […]

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Extreme Diet: The blood thirsty vampire bat

Just in time for Halloween: I came across a preprint in bioRxiv that identified 13 genes missing from vampire bats (Desmodus rotundus), but found in other bat species. Animals that drink blood, or sanguivores, have to deal with a diet that is high in protein but typically lower in fat and sugar. Many of the missing genes are thought to be related to their ability to drink blood and obtain […]

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Tenrecs may shed light on the evolution of body temperature regulation

The common tenrec (Tenrec ecaudatus) just may be a living representative of ancestral placental mammals and they are very interesting when it comes to body temperature regulation and torpor. Torpor is a complex series of physiological changes that reduce an animal’s physical activity as well as heart, breathing and metabolic rates, which also results in decreases in body temperature than can be as low as their surrounding environment. Many mammalian […]

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Frogs are teaching researchers about autism

Dr. Helen Willsey at the University of California San Francisco is seeking to understand how autism develops with the help of frogs. Because frogs produce thousands of embryos at the same time, she is able to quickly study the effects of many different gene alterations in the offspring. While the embryos are at the two-cell stage of development, her laboratory alters genes in just one of the cells using CRISPR-Cas9 […]

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Taller horses are more prone to exercise intolerance

A common cause of exercise intolerance in horses is equine recurrent laryngeal neuropathy (RLN). This is a fancy way of saying that the animals are not able to open their larynx on the left side very well during strenuous exercise, which limits their oxygen intake and ability to exercise. Larger horses, like thoroughbreds, are more prone to developing this condition than smaller breeds. In a new study published in Physiological Genomics […]

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Fish offer clues to fixing broken hearts

About a year ago we talked about how Mexican tetra (Astyanax mexicanus) may hold the clues to treating diabetes. New research shows that is not all these tiny fish can teach us. Researchers at the University College London and the University of Oxford now think these fish may hold clues to regenerating damaged heart tissue. Their findings were published in Cell Reports. Mexican tetra are freshwater fish. Over millions of years, […]

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What do nematodes and humans have in common?

Orthologs are genes present in different species that evolved from a common ancestor. While studies have shown the existence of orthologous genes and proteins in C elegans that are associated with diseases in humans, a new study published in Physiological Genomics examined this question as it relates to reproduction. In the new study, researchers identified a whopping 504 genes in C elegans that have yet to be associated with reproduction in humans whereas […]

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Obesity gene found in Labrador retrievers

Researchers at the University of Cambridge in Britain recently studied ‘willpower’ in pet Labrador retrievers. After allowing each dog to smell a hot dog, the researchers placed the hot dog in a hamster cage and sealed it shut with duct tape. While some dogs showed only mild interest in the sealed-up hot dog, others were fixated on the out-of-reach treat. One dog, named Ash, broke apart the contraption to obtain the treat. This […]

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Secret to safer stem cell therapy or cure for cancer?

Researchers trying to find cures for cancer find naked mole rats rather interesting. Not only are these animals long-lived by rodent standards, they are also resistant to the development of cancer. By long-lived, we are talking up to 30 years! A team of researchers from Hokkaido University and Keio University in Japan have now isolated stem cells from the skin of naked mole rats and induced them to revert back to pluripotent stem […]

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Genetic regulation of horse conformation

In a new study published in Physiological Genomics, researchers explored the role of genetics in the conformation of Tennessee Walking Horses. In other words, how close each animal they sampled looked to an “ideal” Tennessee Walking Horse.  According to Kylee Jo Duberstein (Department of Animal and Dairy Science, University of Georgia), there are five criteria that are examined when evaluating the conformation of a horse. These include “balance, structural correctness, way of going, […]

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