Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Tag Archive for ‘hypoxia’

Remarkable hypoxia and cold tolerance of rodents native to the Tibetan plateau

The plateau zokor (Eospalax baileyi) is an underground dwelling rodent species native to the Tibetan plateau (2000-4200 meters in elevation). A new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology explored how these animals were adapted to extract oxygen from an environment with very low levels (83-88% of atmospheric). Hemoglobin molecules found in red blood cells are responsible for binding oxygen and transporting it to tissues […]

Continue Reading →

High altitude deer mice have less stress?

Animals that live at high altitude have evolved a number of physiological adaptations to deal with the low atmospheric oxygen concentrations (hypoxia). For low altitude acclimated animals, short exposures to high altitude results in activation of the sympathetic nervous system (i.e. the fight or flight response). This is a good thing because activation of this system results in more blood flow, especially to the heart and brain to help protect oxygen […]

Continue Reading →

Lactate directly increases breathing

Hypoxic environments increase ventilation in animals. This helps to bring in more oxygen when environmental levels may be limited. With limited oxygen availability, the body turns to anaerobic metabolism, resulting in the production of lactate ions. These ions are known to indirectly stimulate breathing by lowering blood pH and were more recently discovered to directly stimulate the carotid body to increase breathing. For this reason, lactate ions are thought to […]

Continue Reading →

Hypoxia and anoxia and reoxygenation, Oh my!

There are many examples of animals that can naturally tolerate hypoxic and anoxic conditions without exhibiting pathologies associated with reoxygenation. Here are a few examples from this year’s conference: Dr. Anthony Signore (University of Nebraska) spoke about how some hypoxia tolerant animals can use carbon monoxide, you know that gas we think of as poisonous, to improve oxygen binding to hemoglobin in hypoxic conditions. Well known for their ability to […]

Continue Reading →

How Animals Deal with Stress

  Victor Zhang (Graduate Student working with Dr. Loren Buck at Northern Arizona University) gave an interesting talk on his research to measure stress and activity patterns in free living arctic ground squirrels. They found overall that females were less stressed than males although stress levels and activity varied during lactation. I think some human mothers can agree with those observations. Oliver Wearing (Graduate student working with Dr. Graham Scott […]

Continue Reading →

Study examines link between sleep apnea and cancer

A recent review published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology explored the link between sleep apnea and cancer (4). More and more people are living with sleep apnea. In fact, current estimates indicate that up to 24% of men as well as up to 5% of women have obstructive sleep apnea (4). Individuals with sleep apnea experience repeated cycles of low oxygen (hypoxia) and reoxygenation throughout […]

Continue Reading →

Chocolate: Bad for Fido, good for us?

Many animals, especially dogs and cats, cannot tolerate theobromine which is an alkaloid from the cacao plant. Studies of humans, however, have found many beneficial health effects of theobromine, caffeine as well as flavonoids found in cocoa (Martinez-Pinilla et al., 2015). A new study published in Journal of Applied Physiology examined whether cocoa extract can improve heart health in individuals exercising in hypoxic conditions. Hypoxia (i.e. low atmospheric oxygen) reduces the […]

Continue Reading →