Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Aging

Geriatric bees

Jacob Pithan, a graduate student in the laboratory of Dr. Kendra Greenlee (North Dakota State University), presented their research examining how aging affects exercise performance as well as oxidative health at last month’s Experimental Biology conference in Philadelphia. The oxidative stress theory of aging postulates that aging results from an overproduction of free radicals along with a decrease in antioxidants that can scavenge them. The problem with free radicals is […]

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EB 2022: Modeling human diseases and healthy aging

I sat through a very interesting session at this year’s Experimental Biology conference called, “The Power of Comparative Models for Accelerating Translational Healthspan Research: Underutilized Lab Animals, Companion Pets, Old World Monkeys, and Pumas.” While the title seems to capture the general idea of the symposium, I thought I would share a bit more information about the presenters and their exciting research. Dr. Karyn Hamilton from Colorado State University presented […]

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Hibernation slows down aging

I don’t know about you, but when I see an article claiming to be able to explain “The Biology of Beauty Sleep”, I simply have to read it. Clicking on the title brought me to a news article from the journal Nature Ecology & Evolution that featured a recent study examining the idea of how sleep impacts aging. The burning question of course is whether or not there is any […]

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Understanding genetic factors contributing to COPD

According to a study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, we have a lot in common with fruit flies when it comes to the layer of cells that line our airways. So much so, that researchers claim Drosophila melanogaster are important models for lung diseases such as chronic obstructive pulmonary disease (COPD). COPD is a debilitating disease that claimed the lives of over […]

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Secrets to rockfish longevity revealed

Rockfish have gained the attention of scientists due to their exceptional longevity. Researchers at the University of California, Berkeley sequenced the complete genome of 88 species of rockfish in the Pacific Ocean to try to find clues that could explain their longevity. While some are rather short-lived (ex: calico rockfish, Sebastes dallii, only live around 10 years), longer-lived species, like rougheye rockfish (Sebastes aleutianus), can live to be over 200 […]

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Scientists create personalized stem cells from skin to treat Parkinson’s Disease

Parkinson’s disease is a progressive degenerative disorder that targets the nervous system, mainly dopamine neurons, and impairs muscle movements. As the disease progresses, it can also lead to depression and other neurological symptoms. Current treatments are limited to improving symptoms but are not able to cure the disease. A recent study published in Nature Medicine tested whether stem cells could reverse symptoms associated with Parkinson’s disease. Rather than using fetal […]

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Preventing Atherosclerosis

Researchers have identified variants in the B4GALT1 gene of Amish people that are associated with low levels of LDL (i.e. “bad”) cholesterol and fibrinogen, a gene involved in blood clotting. In fact, people with variants in this gene are 35% less likely to be diagnosed with heart disease. When the variant was expressed in mice, the animals had similar decreases in LDL cholesterol and fibrinogen. Researchers are hoping to create […]

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Anti-aging Vaccine

Scientists have created a vaccine that slows aging, at least in mice. Their findings were recently published in Nature Aging. As we age, the ability for the body to get rid of damaged cells declines, which can lead to inflammation and a host of diseases like cancer, Alzheimer’s disease, as well as atherosclerosis. The vaccine works by triggering the immune system to create antibodies against a specific protein associated with […]

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Can lobsters lead us to the proverbial ‘Fountain of Youth’?

When thinking about lobsters, some people may think of: Aside from being a favorite menu item, did you know that American lobsters (Homarus americanus) are one of the largest bottom dwelling (i.e. benthic) invertebrate in the ocean? In fact, they seem to be able to grow indefinitely and have been observed to reach over 1 meter in length? For this reason, scientists suspect they may be a rather long-lived species […]

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Bioaccumulation of metals in sharks

A new study highlights the impact of metal accumulation (cobalt, manganese, nickel, copper, iron and mercury) on the health of twenty individual sharks representing 8 species that were accidentally caught by fisheries in Brazil. Necropsies of the animals showed high levels of metals in the liver, gills and rectal glands. Perhaps not surprisingly, larger animals had more accumulation of the metals in their gills than smaller animals. Higher accumulation in […]

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