Comparative Physiology

The Science Behind Human Endurance Capabilities

Among mammals, humans are known for having exceptional endurance. For example, persistence hunters can run for 2-5 hours to wear out their prey, while marathoners routinely run ~4.5 hours on average (Schulte et al., 2015). Sure, a cheetah can run fast, but it can’t run as long as a human. How did humans develop such exceptional endurance? When vertebrates moved to dry land, they needed to develop lungs to extract […]

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Little-known functions of the spleen: Q&A with Dr. Frank van Breukelen and Gilbecca Smith, University of Las Vegas

We are excited to feature Dr. Frank van Breukelen and his graduate student, Gilbecca Rae Smith, from the University of Las Vegas, Nevada. They presented exciting new research at the 2024 American Physiology Summit examining some little-known functions of the spleen.  Q: We often associate the spleen with its ability to filter blood and make white blood cells to fight infections. We don’t often consider the importance of its ability to […]

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On the path to preventing white-nose syndrome

This Halloween, we are checking in with our “bat-ty” friends. North American populations of bats have been severely decreased by a deadly fungus, known as Pseudogymnoascus destructans, which results in a disease called ‘white-nose syndrome’. There are currently 13 species of hibernating bats known to have been impacted by the disease (Center for Biological Diversity). Having toured a cave recently, our guide ensured that everyone decontaminated their shoes before entering […]

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Thriving at high altitude

Humans have occupied high altitude environments for over 10,000 years, allowing ample time for some remarkable adaptations to hypoxia. Such adaptations we have already discussed in people living on the Tibetan Plateau (elevation: 4,500 meters on average) include higher breathing rates combined with lower levels of hemoglobin, the molecule that carries oxygen in the blood, compared to lowland populations, which helps prevent mountain sickness as well as the formation of […]

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Physiologists in California meet today to discuss the latest research

The California Society of Physiologists is hosting their annual meeting today at the University of California Davis campus! Adapting to high altitude The keynote address will be given this evening by Dr. Tatum Simonson (Associate Professor, University of California San Diego) who will speak about, “Variation in human responses to low oxygen: Insights from Mount Everest to Machu Picchu.” Together with Dr. Francisco Villafuerte (Universidad Peruana Cayetano Heredia, Lima, Peru) […]

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Time Machine: Homeostasis and ‘The Wisdom of the Body’

In this time machine post, we travel back to 1929 to discuss an article written by Dr. Walter B. Cannon, published in Physiological Reviews. Among other achievements, Dr. Cannon is perhaps best known for being the first to coin the term “homeostasis” and to describe “fight or flight responses” in organisms. As a review article, Dr. Cannon summarized observations made by others about how organisms appear to “maintain their own […]

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From Hibernation to Healing: Unlocking Genomic Secrets for Human Therapies

I was just cleaning my desk and came across an issue of The Physiologist Magazine from March that had ended up under a pile of papers., some of which were admittedly much older. Clearly, I should clean my desk more often. Anyway, in perusing the issue I came across a gem… The March issue featured Dr. Joanna Kelley, associate professor at the University of California Santa Cruz. Dr. Cruz was […]

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New study provides more insight into the physiology of elite divers

If the Olympics allowed marine mammals to compete, they would dominate free diving competitions in terms of breath holding duration and extreme physiology. Marine mammals also have adaptations that help prevent tissue damage from the lack of oxygen during such dives. For example, Weddell and northern elephant seals store large amounts of oxygen in their blood and muscles, thanks to abundant hemoglobin, which permits them to hold their breath for […]

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What dolphins can teach us about healthy aging

The risk of developing cardiovascular disease increases with aging as arteries can become increasingly stiff and the inner lining, called the endothelium, can become dysfunctional. Postdoctoral fellow Dr. Yara Bernaldo De Quiros Miranda (University of Las Palmas de Gran Canaria) is interested in understanding how bottlenose dolphins, Tursiops truncatus, protect their cardiovascular system during aging. She is currently a visiting scholar at the University of Colorado at Boulder where she […]

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