Life Lines by Dr. Dolittle

Covid

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2024 “Ig Nobel” prize-winning research

The results are in (drumroll please). Here are some highlights from the 34th First Annual “Ig Nobel” Prize ceremony held on September 12th at the Massachusetts Institute of Technology. The Ig Nobel prize is designed to recognize “achievements that first make people laugh and then make them think”. Physiology Following the Covid-19 pandemic, an international team of researchers published a study in 2021 eloquently titled, “Mammalian enteral ventilation ameliorates respiratory […]

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Sniffing out pathogens

Rainbow trout are able to mount an immune response after simply smelling a virus or bacteria, even before they are infected. In a new study shared at the 2023 American Physiology Summit, researchers examined whether smell-induced activation of the immune response also triggers avoidance behaviors in the fish. By creating a maze that included a pathogen at one end, they discovered that the fish do in fact avoid the smell […]

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The complex interplay between pathogens and our immune system

I read an interesting review article explaining how cells evolved the ability to kill off pathogens and, in turn, how pathogens evade death. It is kind of like a perpetual game of ‘cat and mouse’ in which the interaction between animals and pathogens drives the evolution of host defenses against infections while at the same time driving the evolution of pathogen strategies to avoid detection. According to the review article, […]

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Mice have special ‘jumping genes’ that help them survive viral infections

Researchers at the University of New South Wales (UNSW), Sydney discovered a ‘jumping gene’ that prevents the immune system of mice from overreacting to a viral infection. Jumping genes are movable nucleic acids, or transposable elements, that make up nearly 2/3 of the genome in mammals. They help regulate the expression of genes. Some transposable elements in the genome are new and some originated in ancient times. In the new […]

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Today’s Feature: Midlands Society of Physiological Sciences

October was a great month for physiology! The Midlands Society of Physiological Sciences also held their virtual annual meeting on October 23rd.  Highlights from Oral Presentations: Lucas Wang, undergraduate student at the University of Nebraska – Omaha (in collaboration with Lie Gao, Bryan Hackfort, and Irving Zucker) presented research exploring how upregulating a pathway in skeletal muscle that protects from oxidative stress and inflammation prevented age-related declines in heart and […]

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Could the ocean hold a cure for Covid-19?

In searching for treatments for Covid-19, researchers discovered that a cancer drug called Aplidin (aka: Plitidepsin), originally isolated from Mediterranean sea squirts, was up to 27.5 times more effective at killing the virus in cell cultures than the FDA-approved drug Remdesivir! Importantly, it was also shown to be effective at preventing the virus from replicating in mice. Sources: Youtube KM White, R Rosales, S Yildiz, T Kehrer, L Miorin, E […]

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Take Time for Activity Snacks

There went another day spent sitting at my computer in virtual meetings with easily accessible snacks in the kitchen nearby. Okay, granted this is not a comparative physiology topic. But it is something many of us can relate to in this age of Covid-19. In a new study published in the Journal of Applied Physiology, researchers explored what happens when people seek out so-called “activity snacks” instead of the salty […]

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Llamas to the rescue?

A couple years back, we talked about how nanobodies created by camelids, such as alpacas and llamas, may lead to the discovery of new disease-fighting drugs. Aptly named, nanobodies are tiny pieces of antibodies that can bind to target proteins more easily than larger antibodies. Researchers in labs around the world are now exploring llama nanobodies for the treatment of Covid-19. Check out the video below released this month by […]

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Feline drug may lead to new Covid-19 treatment

Researchers at Anivive, a pet health drug discovery and commercialization company, are seeking approval to test a new drug for Covid-19 that was originally developed to treat feline intestinal coronavirus. Similar to Covid-19, feline coronavirus is very contagious. In some cats, the virus mutates and leads to feline infectious peritonitis (FIP), which is currently the top cause of death for young cats and kittens (~700,000 cats annually). The new drug, […]

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