Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Could the ocean hold a cure for Covid-19?

Image of a sea squirt from Quantitative Biosciences Institute

In searching for treatments for Covid-19, researchers discovered that a cancer drug called Aplidin (aka: Plitidepsin), originally isolated from Mediterranean sea squirts, was up to 27.5 times more effective at killing the virus in cell cultures than the FDA-approved drug Remdesivir! Importantly, it was also shown to be effective at preventing the virus from replicating in mice.



KM White, R Rosales, S Yildiz, T Kehrer, L Miorin, E Moreno, S Jangra, MB Uccellini, R Rathnasinghe, L Coughlan, C Martinez-Romero, J Batra, A Rojc, M Bouhaddou, JM Fabius, K Obernier, M Dejosez, MJ Guillén, A Losada, P Avilés, M Schotsaert, T Zwaka, M Vignuzzi, KM Shokat, NJ Krogan, A García-Sastre. Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science. eabf4058, 2021.
DOI: 10.1126/science.abf4058

Categories: Covid, Nature's Solutions, Ocean Life

Tags: , , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s