Life Lines by Dr. Dolittle

Environment

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Primed for survival: How sea hares inspire new clues to protect the brain from low oxygen conditions such as stroke

Sea hares (Aplysia californica) live in coastal environments where oxygen levels can fluctuate unpredictably. Knowing this, researchers set out to explore how these animals tolerate regular exposure to hypoxia (low oxygen) with the hope of discovering clues that could teach us how to protect humans from hypoxia-related conditions, such as stroke. To do this, they compared offspring from two types of parents: those collected from the wild that likely experienced […]

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From firefighting foam to feathers: Tracking PFAS in nature

It seems that we are learning more every day about potential exposure to “forever chemicals”, such as PFAS. From proposed laws in California that would ban PFAS in cookware and other items to maps such as the one above showing potential contamination in tap water. These chemicals are drawing so much attention because they do not break down easily and can remain in the environment for decades. In addition, PFAS […]

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Brown adipose tissue: not just a heater or fat-burning machine

Once dismissed as a feature only babies possess, brown adipose tissue (BAT), is widely recognized as the body’s metabolism-boosting, heat-generating fat. This Time Machine episode takes a look back at early research and new discoveries about this metabolism-boosting fat. According to a 2007 paper published in the American Journal of Physiology – Endocrinology and Metabolism, it was the ability for BAT to take up glucose that enabled its discovery in […]

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Red, White, and Bison: Celebrating Freedom and National Bison Month

Happy 4th of July! What a perfect time to also honor National Bison Month! This month, we celebrate an icon of the American landscape. Bison are incredible animals, not just for their symbolic significance but also for their remarkable adaptations to extreme environments. As highlighted by the National Park Service’s Bison Bellows, their resilience in the face of brutal winters is extraordinary. Bison are uniquely adapted to harsh winter conditions […]

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Ocean oddity: how teleost fish stay hydrated in saltwater

It may sound strange to hear that saltwater fish need to stay hydrated. After all, they live in water. However, a review published in Physiology describes how nearly all saltwater fish are thought to have evolved from freshwater ancestors, and many maintain similar levels of salt in their blood as freshwater animals. Living in a saltwater environment means that these fish have to find a way to get rid of […]

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Time Machine: Keeping it hot…or not

In todays’ Time Machine, we are taking a look back at a paper written by Dr. Henry Gray Barbour during his time in the Department of Pharmacology at Yale University School of Medicine. Published in Physiological Reviews in 1921, his paper examined how body heat is regulated in various species. In this review, Dr. Barbour explains that water is the best medium for conducting heat throughout the body. This is […]

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Discovered by accident: Queen bumblebees can hibernate underwater!

Dr. Sabrina Rondeau, a postdoctoral fellow at the University of Ottawa, made a surprising discovery that has created quite the buzz. While checking on queen bumblebees hibernating in the refrigerator, she noticed that condensation had formed inside some of the containers housing the queen bumblebees. Interestingly, the bees survived the ordeal. Intrigued by how exposure to water might affect queen bees during hibernation, Dr. Rondeau conducted an experiment in Bombus […]

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Some like it hot: Genetic twists in warm hibernation

Hibernation was also a hot…I mean warm…topic at the American Physiology Summit last month in Baltimore, MD. Thomas Crippen presented research conducted with team members Dr. Dylan Barth, Zac Carlson, Dr. Frank van Breukelen, and Dr. Allyson Hindle at the University of Nevada, Las Vegas. Their study focused on golden-mantled ground squirrels, Callospermophilus lateralis, which are remarkable even among hibernators. These squirrels can enter torpor across a range of environmental […]

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No air? No problem: Nature’s ultimate survivalists

Hypoxia and anoxia tolerance was a hot topic at the 2025 American Physiology Summit last month. Here are the highlights: Hafsa Yaseen and Natalie Anne Heath presented their research from Dr. Joseph Santin’s laboratory at the University of Missouri exploring how adult bullfrogs (Aquarana catesbeianus) protect their brain function following hibernation, a period when oxygen and glucose levels are often very low. The team discovered that bullfrogs could adjust their […]

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