Life Lines by Dr. Dolittle

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Tag Archive for ‘blood pressure’

Blood flow shifts during diving

In many mammals exposure to hypoxic conditions results in the release of a vasodilator called nitric oxide, which improves blood flow and protects oxygen delivery to tissues throughout the body. Diving animals appear to be unique in that some of their blood vessels stay constricted while they are diving even though they experience hypoxia. A new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology explored […]

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How Ossabaw Island swine are helping us understand obesity and diabetes

         Ossabaw Island off the coast of Georgia (United States) is home to feral swine brought over by early Spanish explorers. In relative isolation on the island, with the exception of the introduction of a Hampshire pig, the Ossabaw pigs have become genetically distinct from those living on the mainland. Ossabaw pigs are prone to obesity and are the only miniature pigs known to develop type 2 […]

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People with diabetes have less sRAGE

When blood sugar concentrations are elevated, humans run the risk of glucose binding to proteins in the blood and causing the irreversible formation of advanced glycation end products (AGE). Once formed, AGEs can bind to their receptor (RAGE) and stimulate inflammation and oxidative stress. This pathological signaling can be stopped by pieces of the RAGE protein that break off and form a soluble version called sRAGE. These soluble versions of […]

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Another primate with spontaneous hypertension

Humans are not the only primates that spontaneously develop hypertension. A new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, examined the development of spontaneous hypertension in African Green Monkeys (Chlorocebus aethiops sabaeus; aka: vervets). The team measured blood pressure in 424 adult monkeys and found that 37% had high blood pressure (SBP: 172.0±2.2 mmHg) and an additional 18% had borderline hypertension. Like humans, […]

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Keeping arteries healthy, lessons from seals?

Heart rate decreases during diving in seals and other animals. Thus the ascending aorta becomes very important during diving as it helps to maintain blood pressure during prolonged dives. A new study published in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology was designed to examine the ascending aorta of hooded seals (Cystophora cristata) and the tiny blood vessels that supply nutrients to it, called the vasa vasorum. The […]

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