Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Improving tissue integrity for transplants

Comparative Mastehead 2018

Ground squirrels are known for their remarkable ability to tolerate hypothermic conditions. Humans are not.

Image of a 13-lined ground squirrel by Laetitia C  via Wikimedia Commons

Dr. JingXing Ou (National Institutes of Health) presented an interesting talk that explored using induced pluripotent neuronal stem cells isolated from these mammalian hibernators to improve tissue integrity for organ transplants. By understanding which pathways protected ground squirrel cells from cold-damage, these pathways could be manipulated in human induced pluripotent neuronal stem cells and improve their stability in cold conditions.

Categories: Comparative Physiology

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