Life Lines by Dr. Dolittle

Sponsored by the American Physiological Society

Komodo dragons have antibacterial blood


Picture of a komodo dragon by CC BY-SA 3.0, via Wikimedia Commons

Researchers studying komodo dragons (Varanus komodoensis) at George Mason University discovered 48 previously unknown peptides in their blood that might have antimicrobial properties. Their findings were published in the Journal of Proteome Research. For the largest lizard, these peptides may help prevent the animals from getting infections from their own saliva, which is host to at least 57 species of bacteria. With this number of bacteria, it is easy to understand why they evolved so many defense mechanisms to prevent infections from their own saliva as well as bite injuries during fights with other dragons.

The researchers isolated and synthesized 8 of the peptides and tested their ability to fight infections. Seven of the peptides were found to have antimicrobial activity against Pseudomonas aeruginosa as well as Staphylococcus aureus whereas the 8th peptide showed antimicrobial activity only towards P. aeruginosa. Thus, for humans these proteins may pave the way for the development of new treatments for antibiotic-resistant bacterial strains.


BM Bishop, ML Juba, PS Russo, M Devine, SM Barksdale, S Scott, R Settlage, P Michalak, K Gupta, K Vliet, JM Schnur, ML van Hoek. Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using Electron-Transfer Dissociation Mass Spectrometry. Journal of Proteome Research. In Press. doi: 10.1021/acs.jproteome.6b00857

Categories: Extreme Animals, Illnesses and Injuries, Nature's Solutions

Tags: , ,

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s