Here is the 4th most popular post so far this year:
The researchers isolated and synthesized 8 of the peptides and tested their ability to fight infections. Seven of the peptides were found to have antimicrobial activity against Pseudomonas aeruginosa as well as Staphylococcus aureus whereas the 8th peptide showed antimicrobial activity only towards P. aeruginosa. Thus, for humans these proteins may pave the way for the development of new treatments for antibiotic-resistant bacterial strains.
BM Bishop, ML Juba, PS Russo, M Devine, SM Barksdale, S Scott, R Settlage, P Michalak, K Gupta, K Vliet, JM Schnur, ML van Hoek. Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using Electron-Transfer Dissociation Mass Spectrometry. Journal of Proteome Research. In Press. doi: 10.1021/acs.jproteome.6b00857
Categories: Comparative Physiology